Many have called it “unfilmable,” but the Wachowski siblings (The Matrix) and Tom Tykwer (Run, Lola, Run) will try their hands at adapting David Mitchell’s Cloud Atlas, beginning in mid-September, according to The Hollywood Reporter.

They face the challenge of adapting a book that connects six stories set in different time periods and locations. The actors will play multiple roles and the production will involve two parallel shoots.

The film stars Tom Hanks, Halle Berry, Hugo Weaving, Susan Sarandon, Ben Whishaw and Jim Broadbent.

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